Sunday, October 27, 2019

Symmers' pipestem fibrosis

Q: What is Symmers' pipestem fibrosis? 


Answer: The periportal fibrosis in Schistosomiasis is called Symmers' pipestem fibrosis.

The clinical course of Schistosomiasis is hallmarked by the host immune response to migrating eggs. Adult worms absorb host proteins and coat themselves with host antigens. This allows them to have a prolonged residence in the bloodstream evading immune attack. indolently, migration of eggs through tissues is associated with entrapment, inflammation, and subsequent fibrosis. Eggs are carried via the splanchnic venous system and may embolize to the liver, lungs, spleen, brain, or spinal cord.


#infectious-diseases

#hepatology


References: 


1. Gryseels B, Polman K, Clerinx J, Kestens L. Human schistosomiasis. Lancet 2006; 368:1106.


2. Pearce EJ. Priming of the immune response by schistosome eggs. Parasite Immunol 2005; 27:265.


3. Keating JH, Wilson RA, Skelly PJ. No overt cellular inflammation around intravascular schistosomes in vivo. J Parasitol 2006; 92:1365. 


4. Coutinho HM, Acosta LP, Wu HW, et al. Th2 cytokines are associated with persistent hepatic fibrosis in human Schistosoma japonicum infection. J Infect Dis 2007; 195:288.

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