Q: Why trazodone is preferred over quetiapine as a sleep aid in ICU?
Answer:
There is no objective verified data on the basis of biochemical studies to prefer one over the other but based on patient-reported and nursing-observed sleep outcomes trazodone is preferred over quetiapine.
Trazodone is a serotonin modulator. It causes a good amount of sedation but is better tolerated than benzodiazepines as it does not cause physiologic tolerance or dependence. It should be used with caution in cardiac patients due to its risk of causing arrhythmias.
#pharmacology
#sleep-in-ICU
References:
1. Doroudgar S, Chou TI, Yu J, et al. Evaluation of trazodone and quetiapine for insomnia: an observational study in psychiatric inpatients. Prim Care Companion CNS Disord 2013; 15.
2. Lenhart SE, Buysse DJ. Treatment of insomnia in hospitalized patients. Ann Pharmacother 2001; 35:1449.
No comments:
Post a Comment