Q: What is the major concern when inhaled nitric oxide (iNO) is administrated via nasal prong, face mask or Non-invasive positive pressure (NIPPV) mask?
Answer: iNO and its derivatives NO2 have direct cytotoxic effects particularly to alveolar and vascular tissue. NO released into the environment can be potentially toxic. If iNO is administered by nasal prongs, face mask or NIPPV than it should be done in a well-ventilated area.
1.Weinberger B, Laskin DL, Heck DE, Laskin JD. The toxicology of inhaled nitric oxide. Toxicol Sci 2001; 59:5.
2. Narula P, Xu J, Kazzaz JA, et al. Synergistic cytotoxicity from nitric oxide and hyperoxia in cultured lung cells. Am J Physiol 1998; 274:L411.
3. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994; 149:538.