Q: Given the pathology of 'capillary leak' in hantavirus cardiopulmonary syndrome (HCPS) - high dose glucocorticoids are valuable in its management?
Despite increased risk of cardiopulmonary collapse and respiratory failure due to capillary leak in hantavirus cardiopulmonary syndrome, glucocorticoids failed to show any benefit and are not recommended as an adjunctive treatment.
1. Vial PA, Valdivieso F, Ferres M, et al. High-dose intravenous methylprednisolone for hantavirus cardiopulmonary syndrome in Chile: a double-blind, randomized controlled clinical trial. Clin Infect Dis 2013; 57:943.