Tuesday, February 4, 2020

Angiotensin 2

Q: Angiotensin II works as a pressor via which electrolyte? 

Answer: calcium 

 Although clinical use of Angiotensin II infusion in ICUs is relatively recent but its mechanism of action is well known for decades. Angiotensin receptors (AT1 and AT2) are G-coupled protein receptors with angiotensin II as their ligand. Angiotensin II is a vasoconstrictor and is a part of the renin-aldosterone-angiotensin (RAAS) system. When receptors are stimulated, it leads to three effects to mediate vasoconstriction and better hemodynamic profile 

 1. cytosolic calcium concentration 

 2 aldosterone secretion 
 3. vasopressin secretion




Catt KJ, Mendelsohn FA, Millan MA, Aguilera G. The role of angiotensin II receptors in vascular regulation. J Cardiovasc Pharmacol 1984; 6 Suppl 4:S575.

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