Q: Angiotensin II works as a pressor via which electrolyte?
Although clinical use of Angiotensin II infusion in ICUs is relatively recent but its mechanism of action is well known for decades. Angiotensin receptors (AT1 and AT2) are G-coupled protein receptors with angiotensin II as their ligand. Angiotensin II is a vasoconstrictor and is a part of the renin-aldosterone-angiotensin (RAAS) system. When receptors are stimulated, it leads to three effects to mediate vasoconstriction and better hemodynamic profile
1. cytosolic calcium concentration
2 aldosterone secretion
3. vasopressin secretion
Catt KJ, Mendelsohn FA, Millan MA, Aguilera G. The role of angiotensin II receptors in vascular regulation. J Cardiovasc Pharmacol 1984; 6 Suppl 4:S575.