Case: 32 year old female in the first trimester of pregnancy, who just returned from a Southeast Asian country is admitted to ICU with severe dysentery. Which of the following antibiotics would you choose? (select one)
A) azithromycin
B) fluoroquinolone
Answer: A
The objective of the above question is to emphasize the rising resistance of fluoroquinolone across the globe particularly in southeast Asian countries. Antibiotics are not indicated for mild travelers' diarrhea but in severe cases, it may require antibiotics. Azithromycin is preferred in severe dysentery, pregnancy, and children. The preferred dose is 1 gram in a single dose, or 500 mg daily for 3 days.
Note: A clue for the right answer in this question is pregnancy. All fluoroquinolones are contraindicated in children, adolescents, pregnant and breastfeeding women.
#infectious-diseases
#Ob-Gyn
#pharmacology
Reference:
Riddle MS, Connor BA, Beeching NJ, et al. Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. J Travel Med 2017; 24:S57.
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