Q: What is the recommended dose and treatment course of hydroxychloroquine in symptomatic COVID-19 patients?
Answer: 200 mg three times per day for 10 days
Both chloroquine and hydroxychloroquine inhibits SARS-CoV-2 at least in vitro. Hydroxychloroquine appears to have more potent antiviral activity than Chloroquine. In COVID-19, some data from China has shown reduced progression of disease and decreased duration of symptoms. The dose is 200 mg three times per day for 10 days.
Some reports suggest that it is associated with a higher rate of undetectable SARS-CoV-2 RNA on nasopharyngeal specimens by day 6 compared with no specific treatment (70 % vs 12.5%). Also, addition of azithromycin in combination with hydroxychloroquine appeared to have additional benefit, although the basis for this benefit is not clear.
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