Friday, April 3, 2020

Propofol and bronchodilation

Q: Propofol has a bronchodilation property?

A) True
B) False

Answer: A 

 Propofol is highly lipophilic phenol derivative, and it can pass through blood-brain barrier. It has amnesic, anxiolytic, anticonvulsant, muscle relaxant and bronchodilation properties. Propofol’s bronchodilating effect is mediated via anticholinergic effects. It produces tracheal relaxation and inhibits contractions induced by histamine and prostaglandin F2-alpha.




1. Hirota K, Sato T, Hashimoto Y et al: Relaxant effect of propofol on the airway in dogs. Anesthesiology 1997; 87: A1116. 

2. Pedersen CM, Thirstrup S, Nielsen-Kudak JE: Smooth muscle relaxant effects of propofol and ketamine in isolated guinea-pig trachea. Eur J Pharmacol 1993; 238: 75-80.

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