Answer: Doxycycline is an extensively broad-spectrum antibiotic, and unfortunately less utilized in developed countries. It is from the tetracycline class. It is
- very cost-effective
- similar intravenous to oral conversion
- no adjustment needed in renal or hepatic insufficiency
- it does not get cleared by any form of dialysis
#pharmacology
#infectious-diseases
References:
1. Heintz BH, Matzke GR, Dager WE. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy. 2009;29(5):562-577. doi: 10.1592/phco.29.5.562
2. Lee P, Crutch ER, Morrison RB. Doxycycline: studies in normal subjects and patients with renal failure. N Z Med J. 1972;75(481):355-358.
3. Letteri JM, Miraflor F, Tablante V, Siddiqi S. Doxycycline (Vibramycin) in chronic renal failure. Nephron. 1973;11(5):318-324.
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