Answer: Doxycycline is an extensively broad-spectrum antibiotic, and unfortunately less utilized in developed countries. It is from the tetracycline class. It is
- very cost-effective
- similar intravenous to oral conversion
- no adjustment needed in renal or hepatic insufficiency
- it does not get cleared by any form of dialysis
1. Heintz BH, Matzke GR, Dager WE. Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy. 2009;29(5):562-577. doi: 10.1592/phco.29.5.562
2. Lee P, Crutch ER, Morrison RB. Doxycycline: studies in normal subjects and patients with renal failure. N Z Med J. 1972;75(481):355-358.
3. Letteri JM, Miraflor F, Tablante V, Siddiqi S. Doxycycline (Vibramycin) in chronic renal failure. Nephron. 1973;11(5):318-324.