Q: In patients with septic shock antibiotics should be started at? (select one)
A) full "high-end" loading dose
B) full "low-end" loading dose
In patients with septic shock, antibiotics should be started at a full "high-end" loading dose if there is no significant contra-indication. This is due to the reason that these patients usually have a increased volume of distribution that occurs due to the administration of intravenous fluid (IVF) resuscitation. Higher clinical success rates are reported with higher peak concentrations of different antibiotics in these patients.
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