Thursday, June 11, 2020

On Dig

Q: Can digoxin be called an inotrope by definition? (select one)

A) Yes
B) No

Answer: A

There are four classes of inotrope and digitalis in one of them. 

  •  Phosphodiesterase inhibitors - Milrinone & Enoximone 
  •  Beta-agonists - High-dose dopamine & Dobutamine 
  • Calcium-sensitizing agents - Levosimendan & oral Pimobendan 
  • Digitalis - Digoxin
All of these drugs have the property of direct inotropic effects and cause an increase in cardiac output.




1. Gheorghiade M, van Veldhuisen DJ, Colucci WS. Contemporary use of digoxin in the management of cardiovascular disorders. Circulation 2006; 113:2556.

2. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 2013; 128:1810.

3. Dec GW. Acute decompensated heart failure: the shrinking role of inotropic therapy. J Am Coll Cardiol 2005; 46:65.

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