Monday, June 22, 2020

Remdesivir and liver

Q: Remdesivir should be discontinued if Liver Funtion Test (LFT) is? 

A) >2 times of normal 
B) >5 times of normal 


 Remdesivir is in use for COVID-19 patients with severe disease. It should be avoided in patients with an estimated glomerular filtration rate (eGFR) less than 30 mL/min per 1.73 m2. Remdesivir also carries the risk of liver failure. Per existing guidelines, remdesivir is not recommended if alanine aminotransferase ≥5 times the upper limit of normal, and/or should be discontinued if it rises above this level during treatment and/or if there is any sign of acute liver failure.



 Boettler T, Newsome PN, Mondelli MU, Maticic M, Cordero E, Cornberg M,Berg T, Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper, JHEP Reports (2020), 

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