Cryoprecipitate in uremic bleeding

Q: How cryoprecipitate helps in uremic bleeding?

Answer:  Cryoprecipitate shortens bleeding time in patients with uremia. Various factors present in Cryoprecipitate like factor VIII, von Willebrand factor multimers and fibrinogen enhances platelet aggregation. 10 units of cryoprecipitate may become effective within one hour of infusion. Cryoprecipitate can be used if standard treatments like platelet transfusion or desmopressin (DDAVP) fails to do the task.

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Reference:

Janson PA, Jubelirer SJ, Weinstein MJ, Deykin D. Treatment of the bleeding tendency in uremia with cryoprecipitate. N Engl J Med 1980; 303:1318.