Wednesday, July 29, 2020

Octreotide in PUD

Q: What are the three beneficial effects of Octreotide in bleeding peptic ulcer?

Answer: Octreotide though commonly used in variceal bleeding is also found to be of benefit in bleeding peptic ulcers. It has three major effects

  •  reducing splanchnic blood flow 
  • inhibiting gastric acid secretion, and 
  • possible gastric cytoprotective effects 

It is usually used as a backup treatment where endoscopy is not feasible for the patient. It is also recommended as an adjunct treatment before endoscopy or failed endoscopy. 



1. Bloom SR, Mortimer CH, Thorner MO, et al. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet 1974; 2:1106. 

2. Johansson C, Aly A. Stimulation of gastric mucus output by somatostatin in man. Eur J Clin Invest 1982; 12:37. 

3. Imperiale TF, Birgisson S. Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Ann Intern Med 1997; 127:1062.

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