Answer: Octreotide though commonly used in variceal bleeding is also found to be of benefit in bleeding peptic ulcers. It has three major effects
- reducing splanchnic blood flow
- inhibiting gastric acid secretion, and
- possible gastric cytoprotective effects
It is usually used as a backup treatment where endoscopy is not feasible for the patient. It is also recommended as an adjunct treatment before endoscopy or failed endoscopy.
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3. Imperiale TF, Birgisson S. Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Ann Intern Med 1997; 127:1062.