Q: Hyperglycemic response to dextrose containing fluid infusion in ICU patients is usually exaggerated. What are the reasons behind it?
It is not a surprise that infusion of dextrose-containing solutions can cause hyperglycemia, but this response is exaggerated particularly in ICU patients. This is due to two other added mechanisms.
1. counter-regulatory hormone response i.e. increased epinephrine secretion.
2. cytokine responses
These all combined effect leads to hyperglycemia much higher than expected.
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