Friday, October 9, 2020

PV and pregnancy

 Q: 32 year old female with a past medical history of Polycythemia Vera (PV) is admitted to ICU after a complication in her first pregnancy with abruptio placentae. You should inform the patient that pregnancy is highly contraindicated in PV? (select one)

A) True

B) False

Answer: B

Despite an increased risk of complications in pregnancy such as miscarriages, abruptio placentae, pre-eclampsia, and intrauterine growth retardation, pregnancy is not a contraindication in patients with PV. A low dose aspirin decreases the rate of pregnancy loss. Patients should be closely monitored throughout the pregnancy. The European LeukemiaNet recommends the target hematocrit either less than 45% or the normal midgestation hematocrit range, whichever is lower. If cytoreduction is needed Interferon alfa is the preferred agent in pregnant women with PV.




1. Barbui T, Barosi G, Birgegard G, et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol 2011; 29:761. 

2. Aggarwal N, Chopra S, Suri V, et al. Polycythemia vera and pregnancy: experience of four pregnancies in a single patient. Arch Gynecol Obstet 2011; 283:393. 

3. Maze D, Kazi S, Gupta V, et al. Association of Treatments for Myeloproliferative Neoplasms During Pregnancy With Birth Rates and Maternal Outcomes: A Systematic Review and Meta-analysis. JAMA Netw Open 2019; 2:e1912666.

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