Saturday, November 21, 2020

alkanization of urine and barbiturates

 Q: Which of the following barbiturate requires alkalinization of urine?

A) short-acting

B) long-acting

Answer: B

Long-acting barbiturates like Phenobarbital requires alkalinization of urine. Short-acting barbiturates metabolized hepatically. When urine is alkalinized a lipid-soluble intact acid or base in the tubular lumen converts into the charged salt. The charged salt becomes lipid-insoluble and cannot move back across the epithelium, and excreted in the urine.

Few other drugs that respond well to alkalinization of urine include chlorpropamide,  salicylates, methotrexate, and sulfonamides. 



1. Henry JA. Specific problems of drug intoxication. Br J Anaesth 1986; 58:223. 

2. Proudfoot AT, Krenzelok EP, Vale JA. Position Paper on urine alkalinization. J Toxicol Clin Toxicol 2004; 42:1.

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