Q: 77 years old female is admitted to ICU with severe urosepsis shock. Disseminated intravascular coagulation (DIC) panel was sent by an on-call resident. Normal fibrinogen level in severe suspected sepsis is a good sign?
Answer: BHypofibrinogenemia is a cardinal feature of acute DIC. On the same token fibrinogen is also an acute phase reactant. So there are two paradox processes occurring in severe sepsis.