Monday, December 28, 2020

Sleep and vent weaning

 Q: Poor sleep quality in ICU leads to prolong weaning from mechanical ventilator? (select)

A) True

B) False


Answer: A

Sleep deprivation has clearly shown to deteriorate the normal respiratory process like hypoxic and hypercapnic chemosensitivity, tongue muscle's (genioglossus) performance, and inspiratory muscles' strength. Sleep studies in ICU have shown poor sleep quality to be associated with prolonged mechanical weaning time, and noninvasive ventilation failure.

#ventilators


References:

1. Thille AW, Reynaud F, Marie D, et al. Impact of sleep alterations on weaning duration in mechanically ventilated patients: a prospective study. Eur Respir J 2018; 51. 

2.  Chen HI, Tang YR. Sleep loss impairs inspiratory muscle endurance. Am Rev Respir Dis 1989; 140:907. 

3. Leiter JC, Knuth SL, Bartlett D Jr. The effect of sleep deprivation on activity of the genioglossus muscle. Am Rev Respir Dis 1985; 132:1242. 

4. Rault C, Sangaré A, Diaz V, et al. Impact of Sleep Deprivation on Respiratory Motor Output and Endurance. A Physiological Study. Am J Respir Crit Care Med 2020; 201:976. 

5. Roche Campo F, Drouot X, Thille AW, et al. Poor sleep quality is associated with late noninvasive ventilation failure in patients with acute hypercapnic respiratory failure. Crit Care Med 2010; 38:477.

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