Q: Diabetes mellitus has a protective effect in an expansion of the Aortic Abdominal Aneurysm (AAA)?
Diabetes mellitus has a negative association and appears to have a protective effect against the expansion of AAA. Diabetic patients have a 25 to 40 percent less chance of expansion of AAA when compared to patients without diabetes. This is due to increased arterial stiffness/atherosclerosis occurring in the aorta due to diabetes. Said that, despite this negative effect on expansion of AAA, it is unknown if this prevents the rupture.
Interestingly, with the same mechanism there is a negative association between the history of coronary artery disease and AAA expansion.
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