Cefiderocol

 Q: Cefiderocol is which generation of cephalosporin? (select one) 

A) First 

B) Second 

C) Third 

D) Fourth 

E) None of the above 

 Answer: E 

Cefiderocol is a very unique cephalosporin and has been granted the status in none of so far developed five generations of cephalosporins. This is due to its novel mechanism of action that can overcome the effect of membrane permeability mutations when transporting across the outer membrane of the organism. Most of its activity is against multidrug-resistant gram-negative bacteria. It has poor gram-positive and anaerobic activity. It is used in the cases where culture grew multidrug-resistant P. aeruginosa, A. baumannii, Stenotrophomonas maltophilia, and Burkholderia cepacia.

#pharmacology

References:

1. Stevens RW, Clancy M. Compassionate Use of Cefiderocol in the Treatment of an Intraabdominal Infection Due to Multidrug-Resistant Pseudomonas aeruginosa: A Case Report. Pharmacotherapy 2019; 39:1113. 

2. Edgeworth JD, Merante D, Patel S, et al. Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa. Clin Infect Dis 2019; 68:1932. 

3. Cefiderocol. US Food and Drug Administration (FDA) approved product information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209445s002lbl.pdf (Accessed on February 3, 2020).