Q: Trazodone is a good choice for patients in ICU with complaints of Restless leg syndrome (RLS)?
Serotonergic agents i.e., trazodone or mirtazapine makes RLS symptoms worse and should not be used exclusively for this purpose. Similarly, benzodiazepine receptor agonists (BZRAs) like zolpidem can also increase the risk for complex sleep-related behaviors.
Drugs recommended for RLS are dopamine agonists such as cabergoline, lisuride, pergolide, pramipexole, ropinirole, and rotigotine. Cabergoline and pramipexole are found to be superior to other dopamine agonists. Also, alpha-2-delta ligands i.e. gabapentin and pregabalin are also found to be useful.
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