Q: 32 years old female on active chemotherapy is recovering in ICU. Oncology service wants to restart her chemotherapy cycle with Cisplatin. Patient request anti-emetic prior to her chemotherapy agent. A chemotherapy agent can be anticipated for the risk of its emetic properties (risk of inducing vomiting)?
A) True
B) False
Answer: A
Fortunately, a chemotherapy agent can be fairly accurately predicted for its risk of causing chemotherapy-induced-nausea-vomiting (CINV). This helps a clinician to prescribe prophylaxis for chemotherapy. Broadly, they are divided into four categories.
- Highly emetic – >90% risk of emesis
- Moderately emetic – 30 to 90% risk of emesis
- Low emetogenicity – 10 to 30% risk of emesis
- Minimally emetic – < 10% risk of emesis
Many centers follow proper CINV protocol in this regard.
#oncology
References:
1. Roila F, Hesketh PJ, Herrstedt J, Antiemetic Subcommitte of the Multinational Association of Supportive Care in Cancer. Prevention of chemotherapy- and radiotherapy-induced emesis: results of the 2004 Perugia International Antiemetic Consensus Conference. Ann Oncol 2006; 17:20.
2. Roila F, Molassiotis A, Herrstedt J, et al. 2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients. Ann Oncol 2016; 27:v119.
3. Hesketh PJ, Kris MG, Basch E, et al. Antiemetics: ASCO Guideline Update. J Clin Oncol 2020; 38:2782.
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