strategies to decrease steroids side effects

 Q: Locally acting glucocorticoids have a lesser risk of superimposed infections than systemic glucocorticoids? 

 A) True 

B) False 

Answer: A

There are various strategies to reduce the risk of superimposed infections. Some of the strategies which can be considered are:

1. Applying glucocorticoids directly to the area/system which is targeted such as a nebulizer or inhaler for respiratory disease, or an oral steroid with high, first-pass metabolism like budesonide for intestinal inflammation. 

2. Alternate-day dosing if clinically appropriate. Prednisone effect may last up to 36 hours, and dexamethasone effect may last up to 72 hours.

3. Early mobilization and physical therapy to counter myopathy. 

#pharmacology

References:

1. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 1976; 84:304.