Q: Amiodarone ____________ the efficacy of sildenafil? (select one)
Sildenafil has been increasingly used in ICU for pulmonary hypertension. Simultaneously these patients are prone to arrhythmia particularly atrial fibrillation, requiring amiodarone for rapid ventricular rate (RVR) control.
Amiodarone interacts with many drugs commonly used in ICU and as a rule of thumb increases the efficacy, and subsequently the potential of their side effects. Some of these drugs include digoxin, warfarin, simvastatin, sildenafil, cyclosporine, and many hepatically metabolized drugs such as antidepressants.
References:1. Colunga Biancatelli RM, Congedo V, Calvosa L, Ciacciarelli M, Polidoro A, Iuliano L. Adverse reactions of Amiodarone. J Geriatr Cardiol. 2019;16(7):552-566. doi:10.11909/j.issn.1671-5411.2019.07.004