Wednesday, August 4, 2021

DPP-4 side effects

 Q: 54 years old obese male with a long-standing type 2 Diabetes Mellitus (DM-2) is admitted to ICU with acute abdominal pain as well as shortness of breath associated with pedal edema. A few weeks ago, Sitagliptin was added to the drug regimen of his diabetic management. What are the few differential diagnoses? 

Answer: Dipeptidyl peptidase 4 (DPP-4) is getting popular in outpatient clinics for the management of DM-2. DPP-4 is a Glucagon-like peptide 1 (GLP-1)-based therapy. It is an effective medicine as it works through various mechanisms which are attractive to clinicians including an increase glucose-dependent insulin secretion, decrease gastric emptying (decrease food intake - weight loss), and reduce postprandial glucagon. Another attractive feature is the rare occurrence of hypoglycemia with its use. 

Said that it is still not considered the first line of therapy in DM-2.

The drugs included in this class are Sitagliptin, Saxagliptin, Linagliptin, and Alogliptin. There are few side effects which in-patients physicians need to be aware of: 
  • Exacerbation of congestive heart failure (CHF) 
  • Nasopharyngitis 
  • Acute pancreatitis 
  • Hepatitis 
  • Inflammatory bowel disease 
  • Severe skin reactions 
  • Severe joint pain 
  • Myalgias and muscle spasms

#endocrinology
#pharmacology


References:

1. Filippatos TD, Athyros VG, Elisaf MS. The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors [corrected]. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):787-812. doi: 10.1517/17425255.2014.907274. Epub 2014 Apr 19. Erratum in: Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1455. PMID: 24746233. 

2. Wu S, Chai S, Yang J, Cai T, Xu Y, Yang Z, Zhang Y, Ji L, Sun F, Zhan S. Gastrointestinal Adverse Events of Dipeptidyl Peptidase 4 Inhibitors in Type 2 Diabetes: A Systematic Review and Network Meta-analysis. Clin Ther. 2017 Sep;39(9):1780-1789.e33. doi: 10.1016/j.clinthera.2017.07.036. Epub 2017 Aug 18. PMID: 28827024.

3. Kasina SVSK, Baradhi KM. Dipeptidyl Peptidase IV (DPP IV) Inhibitors. [Updated 2021 Jun 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542331/

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