Linezolid side-effects

 Q: Thrombocytopenia due to Linezolid is more common in? (select one) 

A) Liver Insufficiency 

B) Renal insufficiency 

 Answer: B 

 Linezolid-induced thrombocytopenia is the least bothered entity as it is usually resolved with the discontinuation of the drug. Some of the other side-effects can be irreversible and may actually prove fatal like peripheral neuropathy, lactic acidosis, and ocular toxicity. Another concern with its use in ICU is development of serotonin syndrome. 

Thrombocytopenia is more common in patients with end-stage kidney disease (ESRD).

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References:

1. Kishor K, Dhasmana N, Kamble SS, Sahu RK. Linezolid Induced Adverse Drug Reactions - An Update. Curr Drug Metab. 2015;16(7):553-9. doi: 10.2174/1389200216666151001121004. PMID: 26424176. 

2. Hashemian SMR, Farhadi T, Ganjparvar M. Linezolid: a review of its properties, function, and use in critical care. Drug Des Devel Ther. 2018;12:1759-1767. Published 2018 Jun 18. doi:10.2147/DDDT.S164515 

3. Wu VC, Wang YT, Wang CY, et al. High frequency of linezolid-associated thrombocytopenia and anemia among patients with end-stage renal disease. Clin Infect Dis 2006; 42:66. 

4. Lawrence KR, Adra M, Gillman PK. Serotonin toxicity associated with the use of linezolid: a review of postmarketing data. Clin Infect Dis 2006; 42:1578.