ETOH in ethylene Glycol toxicity

 Q: ETOH can be given orally in Ethylene Glycol toxicity?

A) Yes

B) No

Answer: A

Although Fomepizole is now the standard treatment for ethylene glycol toxicity, ETOH is still a viable treatment. 

ETOH/distilled spirits (40 to 50% volume/volume) should be diluted to a 20 percent solution and can be given via oral or via nasogastric tube at 5 mL/kg of a 20 percent solution to raise serum concentrations by 100 mg/dL. It should be continued as 0.5 mL/kg/hour for the maintenance dose.

#toxicology

References:

1. Sasanami M, Yamada T, Obara T, Nakao A, Naito H. Oral Ethanol Treatment for Ethylene Glycol Intoxication. Cureus. 2020;12(12):e12268. Published 2020 Dec 25. doi:10.7759/cureus.12268 

2. Achappa B, Madi D, Kanchan T, Kishanlal NK. Treatment of Ethylene Glycol Poisoning with Oral Ethyl Alcohol. Case Rep Med. 2019 Jan 30;2019:7985917. doi: 10.1155/2019/7985917. PMID: 30838047; PMCID: PMC6374870.