Q: Mixed cryoglobulinemia may give false? (select one)
The objective of this question is to highlight the importance of blood smears. In many conditions, automated counter machines may give erroneous values. One example is mixed cryoglobulinemia. When a blood sample is tested at a temperature ≤30°C, precipitated cryoglobulin particles get falsely counted as platelets. To obtain true platelet count in a patient with mixed cryoglobulinemia the blood sample needs to be maintained at body temperature until the testing.
Other conditions which may cause pseudothrombocytosis by the automated counter machine are leukemia or lymphoma cells, hemolysis, or burns where circulating cytoplasmic fragments or fragmented red cells may be falsely read as platelets.
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