Saturday, July 30, 2022

PD-5 I and LUTS

Q: Male patients using Phosphodiesterase 5 (PDE-5) inhibitors may experience increased urinary frequency and urgency.

A) True
B) False

Answer: B

In contrast to the statement in the above question, irrespective of improvement in erectile dysfunction, PDE-5 inhibitors have been found to improve lower urinary tract Symptoms (LUTS), particularly in male patients. 



1. Liu L, Zheng S, Han P, Wei Q. Phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a systematic review and meta-analysis. Urology 2011; 77:123.

2. Gacci M, Corona G, Salvi M, et al. A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 2012; 61:994.

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