Q: Angiotensin-converting enzyme (ACE) inhibitors tend to cause? (select one)
A) hypoglycemia
B) hyperglycemia
Answer: A
Many of the commonly prescribed drugs in ICU tend to cause hypoglycemia. Some are known, and some are less well known. Some important drugs to remember are quinolones, pentamidine, quinine, beta-blockers, and ACE inhibitors.
Said that insulin continued to be the primary cause of hypoglycemia in ICU, where automated protocols are applied in a quest to achieve tighter blood glucose control.
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#pharmacology
References:
1. Murad MH, Coto-Yglesias F, Wang AT, et al. Clinical review: Drug-induced hypoglycemia: a systematic review. J Clin Endocrinol Metab 2009; 94:741.
2. Parekh TM, Raji M, Lin YL, et al. Hypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas. JAMA Intern Med 2014; 174:1605.
3. Cryer PE, Axelrod L, Grossman AB, et al. Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2009; 94:709.
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