Tuesday, December 20, 2022

Other uses of nimodipine

Q; Besides its use to prevent vasospasm in subarachnoid hemorrhage, give at least one less common indication of Nimodipine?


Answer: seizure prophylaxis in Pregnancy Induced Hypertension (previously known as preeclampsia

Though not as effective, it can be used as an alternative or an adjuvant to magnesium for seizure prophylaxis in women with severe preeclampsia. Also, it has some adjuvant value in the treatment of intractable seizures.

Nimodipine has been originally designed to treat high blood pressure but is no longer in use for this indication. Also, FDA has a warning against converting Nimodipine capsules as an IV solution.

#neurology
#Ob-gyn
#cardiovascular


References: 

1. Belfort MA, Anthony J, Saade GR, Allen JC Jr; Nimodipine Study Group. A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia. N Engl J Med. 2003 Jan 23;348(4):304-11. doi: 10.1056/NEJMoa021180. PMID: 12540643.

2. Meyer FB, Cascino GD, Whisnant JP, Sharbrough FW, Ivnik RJ, Gorman DA, Windschitl WL, So EL, O'Fallon WM. Nimodipine as an add-on therapy for intractable epilepsy. Mayo Clin Proc. 1995 Jul;70(7):623-7. doi: 10.4065/70.7.623. PMID: 7791383.

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