Q: Name at least 3 antibiotics/medicines that may be used as adjuvants in treating C. diff. colitis along with Fidaxomicin, Metronidazole, or oral Vancomycin.
Answer:
Many antibiotics have shown partial or full activity against C. Diff. To name a few for use, particularly in suspected relapsing outbreaks, are:
- Rifampin
- Linezolid
- Teicoplanin
- Cholestyramine (anion-exchange resin agent)
- Nitazoxanide
- Rifaximin
- Tinidazole
- Probiotics
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#pharmacology
References:
1. Oksi J, Anttila VJ, Mattila E. Treatment of Clostridioides (Clostridium) difficile infection. Ann Med. 2020 Feb-Mar;52(1-2):12-20. doi: 10.1080/07853890.2019.1701703. Epub 2019 Dec 13. PMID: 31801387; PMCID: PMC7877971.
2. Kelly CR, Fischer M, Allegretti JR, LaPlante K, Stewart DB, Limketkai BN, Stollman NH. ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections. Am J Gastroenterol. 2021 Jun 1;116(6):1124-1147. doi: 10.14309/ajg.0000000000001278. Erratum in: Am J Gastroenterol. 2022 Feb 1;117(2):358. PMID: 34003176.
3. Normington C, Chilton CH, Buckley AM. Clostridioides difficile infections; new treatments and future perspectives. Curr Opin Gastroenterol. 2024 Jan 1;40(1):7-13. doi: 10.1097/MOG.0000000000000989. Epub 2023 Nov 9. PMID: 37942659; PMCID: PMC10715702.
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