Q: Name at least one disease besides severe C. diff. Colitis in which Fecal Microbiota Transplantation (FMT) may be helpful?
Answer: Irritable Bowel Syndrome (IBS)
Although IBS is described as a brain-gut disease, numerous pharmacological and non-pharmacological modalities have been tried. Unfortunately, some patients may fail to respond to all the endeavors. There is weak evidence that fecal microbiota (stool) transplantation may help. FMT is usually performed via colonoscopy. FMT is said to be more helpful in the IBS-diarrhea form.
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References:
1. Johnsen PH, Hilpüsch F, Cavanagh JP, et al. Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial. Lancet Gastroenterol Hepatol 2018; 3:17.
2. El-Salhy M, Hausken T, Hatlebakk JG. Increasing the Dose and/or Repeating Faecal Microbiota Transplantation (FMT) Increases the Response in Patients with Irritable Bowel Syndrome (IBS). Nutrients 2019; 11.
3. El-Salhy M, Winkel R, Casen C, Hausken T, Gilja OH, Hatlebakk JG. Efficacy of Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome at 3 Years After Transplantation. Gastroenterology. 2022 Oct;163(4):982-994.e14. doi: 10.1053/j.gastro.2022.06.020. Epub 2022 Jun 14. PMID: 35709830.
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