Type-3c Diabetes Mellitus

Q: What is type 3C diabetes?

Answer: Pancreatogenic diabetes

Pancreatogenic diabetes is usually a complication of Chronic pancreatitis and sometimes pancreatic cancer.

Long-standing chronic pancreatitis causes a wide range of exocrine insufficiency, leading to metabolic consequences. These include osteopenia, osteoporosis, bone fractures, pancreatogenic diabetes, and opioid dependency due to frequently prescribed narcotics. It may also cause pseudocyst formation, bile duct or duodenal obstruction, pancreatic ascites, pancreatic pleural effusion, splenic vein thrombosis, arterial pseudoaneurysms, small intestinal bacterial overgrowth, gastroparesis, pancreatic ductal adenocarcinoma.

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References:

1. Hart PA, Bellin MD, Andersen DK, et al. Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer. Lancet Gastroenterol Hepatol 2016; 1:226.

2. Vonderau JS, Desai CS. Type 3c: Understanding pancreatogenic diabetes. JAAPA. 2022 Nov 1;35(11):20-24. doi: 10.1097/01.JAA.0000885140.47709.6f. PMID: 36219100.

3. Bhattamisra SK, Siang TC, Rong CY, Annan NC, Sean EHY, Xi LW, Lyn OS, Shan LH, Choudhury H, Pandey M, Gorain B. Type-3c Diabetes Mellitus, Diabetes of Exocrine Pancreas - An Update. Curr Diabetes Rev. 2019;15(5):382-394. doi: 10.2174/1573399815666190115145702. PMID: 30648511.