Heyde's syndrome

Q: Heyde syndrome is an association of gastrointestinal (GI) angiodysplasia and? - select one

A) Mitral stenosis

B) Aortic stenosis

Answer: B

The association between aortic stenosis (AS) and GI angiodysplasia's bleeding is called Heyde syndrome. The common driver is proposed to be Acquired von Willebrand syndrome (AVWS), although some experts question this, as patients may have normal VWF levels. 

Another more plausible explanation is decreased GI perfusion from AS.

#cardiology

#hematology

#GI

References:

1. Vincentelli A, Susen S, Le Tourneau T, et al. Acquired von Willebrand syndrome in aortic stenosis. N Engl J Med 2003; 349:343.

2. Kapila A, Chhabra L, Khanna A. Valvular aortic stenosis causing angiodysplasia and acquired von Willebrand's disease: Heyde's syndrome. BMJ Case Rep 2014; 2014.

3. Mondal S, Hollander KN, Ibekwe SO, Williams B, Tanaka K. Heyde Syndrome-Pathophysiology and Perioperative Implications. J Cardiothorac Vasc Anesth. 2021 Nov;35(11):3331-3339. doi: 10.1053/j.jvca.2020.10.003. Epub 2020 Oct 8. PMID: 33132021.