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Sodium bicarbonate and THAM have a similar alkalinizing effect in patients with mild metabolic acidosis.
- Effect of sodium bicarbonate is longer lasting.
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Sodium bicarbonate decrease serum potassium, but THAM does not.
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THAM tends to decrease serum sodium (THAM may be the alkalinizing agent of choice in patients with hypernatremia)
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Sodium bicarbonate increases PaCO2 and THAM decreases PaCO2.
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