Tuesday, December 3, 2013

THAM vs Sodium Bicarbonate in Metabolic acodosis


  • Sodium bicarbonate and THAM have a similar alkalinizing effect in patients with mild metabolic acidosis.
  • Effect of sodium bicarbonate is longer lasting.
  • Sodium bicarbonate decrease serum potassium, but THAM does not.
  • THAM tends to decrease serum sodium  (THAM may be the alkalinizing agent of choice in patients with hypernatremia)
  • Sodium bicarbonate increases PaCO2 and THAM decreases PaCO2.

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