Q: Beside Erectile Dysfunction (ED) and Pulmonary Hypertension (PAH), Sildenafil is an acceptable treatment in which condition?
Answer: Altitude sickness
The phosphodiesterase 5 (PDE-5) inhibitors (both, sildenafil and tadalafil) have effectively shown to prevent hypoxic pulmonary hypertension. They have used for the prevention as well as treatment of high-altitude pulmonary edema occur in altitude sickness. Different doses have been described for sildenafil, from a single dose of 50 or 100 mg just prior to exposure for acute ascent, to 40 mg three times a day while at high altitude. For tadalafil, 10 mg every 12 hours is the described dose.
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