Q: No adjustment is needed for Linezolid in ESRD (Renal failure) patients. But what is the recommendation for patients on Hemodialysis (HD)?
Answer: Though there is no adjustment needed for Linezolid (Zyvox) in ESRD patients, it should be administrated after HD session as linezolid clearance is increased by 80% during intermittent hemodialysis.
Fifty percent of a linezolid dose is metabolized in the liver to 2 inactive metabolites, and 30% of the dose is excreted in the urine as unchanged drug. There is no adjustment recommended for patients with renal failure; however, it should be administrated after HD.
No linezolid dosage adjustment is recommended for patients receiving CRRT.