Sunday, July 27, 2014

A note on simvastatin and amiodarone interaction


Usage of Simvastatin is generally very high in US population. Amiodarone  is a very frequently use IV medicine in ICUs mostly for  rate control in A.Fib./RVR. If use together, there is a high risk of rhabdomyolysis, leading to life threatening kidney failure. This interaction is dose-dependent with simvastatin doses exceeding 20 mg. 

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