Sunday, July 20, 2014

Q: One of the measure to correct severe metabolic acidosis during or after cardiac bypass surgery is to use Tris-Hydroxymethyl Aminomethane (THAM). How it is used?


Tham Solution has been found to be very effective in correcting metabolic acidosis which may occur during or immediately following cardiac bypass surgery. If chest is open, 2-6 g of THAM can be injected directly into ventricular cavity, avoiding injection in cardiac muscles. Otherwise, it can be given intravenously with following formula

Tham Solution (mL of 0.3 M) required = Body Weight (kg) x Base Deficit (mEq/L) x 1.1

or simply 9 mL/kg IV

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