Q: One of the measure to correct severe metabolic acidosis during or after cardiac bypass surgery is to use Tris-Hydroxymethyl Aminomethane (THAM). How it is used?

Answer: 

Tham Solution has been found to be very effective in correcting metabolic acidosis which may occur during or immediately following cardiac bypass surgery. If chest is open, 2-6 g of THAM can be injected directly into ventricular cavity, avoiding injection in cardiac muscles. Otherwise, it can be given intravenously with following formula

Tham Solution (mL of 0.3 M) required = Body Weight (kg) x Base Deficit (mEq/L) x 1.1

or simply 9 mL/kg IV