Saturday, July 19, 2014

Q: What is the formula for Lactic acid Clearance?

Lactic acid clearance = the initial lactate - subsequent lactate/initial lactate × 100

It is estimated that an 11% decrease in mortality for each 10% decrease in lactate clearance.


1. Arnold RC, Shapiro NI, Jones AE, et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock 2009;32(1):35–39

2. Nguyen HB, Rivers EP, Knoblich BP, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004;32(8):1637–1642

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