Q: Which life-threatening pulmonary complication may happen with Daptomycin infusion

Answer: Eosinophillic Pneumonia

Per FDA report, seven confirmed cases of eosinophilic pneumonia were identified between 2004 and 2010 and an additional 36 possible cases. The seven confirmed cases were all older than 60 and symptoms appeared within two weeks of initiation of therapy.

Reference:

Acute Eosinophilic Pneumonia Secondary to Daptomycin: A Report of Three Cases - Becky A. Miller, Alice Gray, Thomas W. LeBlanc, Daniel J. Sexton, Andrew R. Martin, and Thomas G. Slama - Clin Infect Dis. (2010) 50 (11): e63-e68.