Q: At what level of CPK, you should be vigilant in preventing ARF (Acute Renal Failure), mostly with IVF as mainstay of treatment?

Answer: 6,000 IU/L

Acute Renal Failure develops in almost 40% of patients with rhabdomyolysis. Precipitation of myoglobin and uric acid crystals within renal tubules along with decreased glomerular perfusion may cause acute tubular necrosis (ATN). As low as CPK level around 6000 IU/L, ATN may strike the patient.



Reference:

Ward MM. - Factors predictive of acute renal failure in rhabdomyolysis. Arch Intern Med. Jul 1988;148(7):1553-7.