Q:  What advantage Linezolid has over Vancomycin in MRSA pneumonia?

Answer:  Penetration of linezolid into bronchial fluids is much higher than that of vancomycin. Also, linezolid has high bioavailability and allows easy switching to oral therapy. Moreover, It does not require any adjustment in kidney dysfunction. But, high cost of the drug still makes vancomycin a preferred choice over linezolid.