Wednesday, September 3, 2014

Q:  52 year old male is admitted to ICU as "Pre-op" CABG patient. Previous admission record showed patient with diagnosis of HIT (Heparin Induced Thrombocytopenia) 2 years ago. You rechicked HIT test and OD (optimal density) for HIT is reported as 0.2. What would be your advise on use of Heparin?

Answer:  Patients with previous history of HIT but now with negative antibodies can have heparin during CBP but it should be avoided pre or post surgery.


1. Follis F, Schmidt CA. Cardiopulmonary bypass in patients with heparin-induced thrombocytopenia and thrombosis. Ann Thorac Surg. 2000;70:2173-2181.

2. Warkentein TE. Heparin-induced thrombocytopenia: pathogenesis, frequency, avoidance and management. Drug Safety. 1997;17:325-341.

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