Monday, November 17, 2014

Q: 36 year old female, who is now recouping from exacerbation of Asthma in ICU and just finished her breakfast with large cup of coffee went into sustained SVT with heart rate of 240. You decided to administer Adenosine. What would be your concern?

Answer: Patient may need higher dose

Theophylline (which this patient may have use for Asthma) and caffeine antagonize adenosine's effects, so standard dose of 6 mg IV bolus may not work and an increased dose of adenosine may be required. On the contrary, Dipyridamole potentiates the action of adenosine, requiring the use of half of the standard dose.

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