Wednesday, November 5, 2014

Q: 74 year old male with Parkinson's Disease is admitted to ICU with Urosepsis. Patient is recovering well. A night before transfer to floor, patient start displaying signs of delirium and psychosis. Which anti-psychotic would be of use?



Answer: Quetiapine
Quetiapine and clozapine are recommended for the treatment of Parkinson's disease related psychosis because of their low extrapyramidal side effects. Clozapine is known for some heavy side effects alike agranulocytosis, therefore quetiapine would be considered as a better choice. 




Reference:

Shotbolt P, Samuel M, David A (November 2010). "Quetiapine in the treatment of psychosis in Parkinson’s disease". Therapeutic Advances in Neurological Disorders 3 (6): 339–350

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