A note on use of Methyl Prednisolone in acute Reversal of anti-platelets

There is some literature that exist on rapid reduction in the platelet inhibition following intravenous injection of methyl prednisolone in patients receiving clopidogrel, aspirin and other thienopyridines - who may be acutely bleeding. The beneficial effect of methyl prednisolone is may be due to ADP-mediated platelet inhibition. Rapid reversal of antiplatelet activity by steroid, particularly in intra-cranial bleed patients, is of interest and significance as it may prevent hematoma expansion. No specific dose is specified but any dose from 20-80 mg can be used.