A note on Vitamin C Resuscitation in "Burn Patient"

The landmark "Tanaka study" showed that high dose Vitamin C (ascorbic acid) during the first 24 hours after burn

•  reduced resuscitation fluid requirements by 40%, 
•  reduced burn tissue water content 50%

 All these eventually lead to reduced requirement for mechanical ventilation and reduced ventilator days. 


References: 

1. Tanaka H, Matsuda T, Miyagantani Y, et al: Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration. Arch Surg 2000; 135:326–331 

2. Dubick MA, Williams C, Elgjo GI, et al: High-dose vitamin c infusion reduces fluid requirements in the resuscitation of burn-injured sheep. Shock 2005; 24:139–144